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Title: ARR (Adamantyl Retinoid Related molecules)-miRNA-Cancer      
dateReleased:
06-30-2015
description:
The adamantly-substituted retinoid related (ARR) molecules have been found to induce apoptosis in a variety of malignant cells both in vitro and in vivo. A number of mechanisms have been proposed by which apoptosis is achieved by this class of molecules. We have previously demonstrated that ARRs are potent inducers of apoptosis in leukemia and pancreatic cancer cells. We designed experiments that the exposure of leukemia and pancreatic cancer cell lines to the 3-Cl-AHPC ((E)-4-[3-(1-adamantyl)-4-hydroxyphenyl]-3-chlorocinnamic acid )may result in the modulation of microRNA expression or repression and that this differential microRNA expression may contribute to ARR-mediated inhibition of cellular proliferation and cell death induction.
privacy:
not applicable
aggregation:
instance of dataset
ID:
E-MTAB-1482
refinement:
raw
keywords:
functional genomics
dateModified:
06-09-2014
creators:
Lulu Farhana
availability:
available
types:
gene expression
name:
Homo sapiens
ID:
A-MEXP-2289
name:
Agilent human micoRNA microarray (8x15k), Grid Name 021827
accessURL: https://www.ebi.ac.uk/arrayexpress/files/E-MTAB-1482/E-MTAB-1482.raw.1.zip
storedIn:
ArrayExpress
qualifier:
gzip compressed
format:
TXT
accessType:
download
authentication:
none
authorization:
none
accessURL: https://www.ebi.ac.uk/arrayexpress/files/E-MTAB-1482/E-MTAB-1482.processed.1.zip
storedIn:
ArrayExpress
qualifier:
gzip compressed
format:
TXT
accessType:
download
authentication:
none
authorization:
none
abbreviation:
EBI
homePage: http://www.ebi.ac.uk/
ID:
SCR:004727
name:
European Bioinformatics Institute
homePage: https://www.ebi.ac.uk/arrayexpress/
ID:
SCR:002964
name:
ArrayExpress
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