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Title: PRD1-BF1 drives VEGF-mediated innate immune suppression in tumor vasculature      
dateReleased:
07-10-2015
description:
Our experiments have demonstrated that VEGF signalling is a critical component of oncolytic virus infection in tumor vasculature. This effect is in part mitigated by downstream activation of the master immunoloigcal transcriptional repressor known as PRD/BF1. To investigate the role of the VEGF-PRD/BF1 signalling axis in the context of oncolytic virus infection, we isolated the RNA from sub-confluent human umbilical vein endothelial cells treated under four conditions (siRNA Control, siRNA Control + WyTK-, siRNA Control + WyTK- + VEGF165 and siRNA PRD/BF1 + WyTK- + VEGF165. Using the RNA pooled from four experiments, the goal of this study was to determine the nature & fraction of genes repressed by VEGF in the context of infection, which could be rescued by PRD/BF1.
privacy:
not applicable
aggregation:
instance of dataset
ID:
E-MTAB-2963
refinement:
raw
dateSubmitted:
02-28-2013
keywords:
functional genomics
dateModified:
07-10-2015
creators:
Cory Batenchuk
availability:
available
types:
gene expression
name:
Homo sapiens
ID:
A-GEOD-16686
name:
[HuGene-2_0-st] Affymetrix Human Gene 2.0 ST Array [transcript (gene) version]
accessURL: https://www.ebi.ac.uk/arrayexpress/files/E-MTAB-2963/E-MTAB-2963.raw.1.zip
storedIn:
ArrayExpress
qualifier:
gzip compressed
format:
TXT
accessType:
download
authentication:
none
authorization:
none
accessURL: https://www.ebi.ac.uk/arrayexpress/files/E-MTAB-2963/E-MTAB-2963.processed.1.zip
storedIn:
ArrayExpress
qualifier:
gzip compressed
format:
TXT
accessType:
download
authentication:
none
authorization:
none
abbreviation:
EBI
homePage: http://www.ebi.ac.uk/
ID:
SCR:004727
name:
European Bioinformatics Institute
homePage: https://www.ebi.ac.uk/arrayexpress/
ID:
SCR:002964
name:
ArrayExpress

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