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Title: Leishmania major infection-induced changes in the small RNA transcriptome of host macrophages      
dateReleased:
08-03-2015
description:
Protozoan parasites of the genus Leishmania are the causative agent of leishmaniasis, one of the 13 most important tropical diseases. Leishmania persists as endo-parasite in host macrophages, where it uses multiple strategies to manipulate the microbicidal host cell functions and to escape from the host immune system. Understanding how Leishmania interacts with host macrophages during uptake, differentiation, intracellular replication, and release might be the key to develop new drugs in target-directed approaches to treat patient with leishmaniasis. Short non-coding RNAs are known to regulate the expression of protein-coding genes at post-transcriptional level. Characterization of these processes during Leishmania infection provides deeper insight in the interaction between host and parasites. Here, we generated miRNA expression profiles from bone marrow-derived macrophages (BMDM) at 4h and 24h post infection (p.i.) with Leishmania major and respective controls.
privacy:
not applicable
aggregation:
instance of dataset
ID:
E-GEOD-58369
refinement:
raw
alternateIdentifiers:
58369
keywords:
functional genomics
dateModified:
08-19-2015
availability:
available
types:
gene expression
name:
Mus musculus
ID:
A-GEOD-16384
name:
[miRNA-3] Affymetrix Multispecies miRNA-3 Array [miRNA-3_0] or [miRNA-3_1]
accessURL: https://www.ebi.ac.uk/arrayexpress/files/E-GEOD-58369/E-GEOD-58369.raw.1.zip
storedIn:
ArrayExpress
qualifier:
gzip compressed
format:
TXT
accessType:
download
authentication:
none
authorization:
none
accessURL: https://www.ebi.ac.uk/arrayexpress/files/E-GEOD-58369/E-GEOD-58369.processed.1.zip
storedIn:
ArrayExpress
qualifier:
gzip compressed
format:
TXT
accessType:
download
authentication:
none
authorization:
none
accessURL: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE58369
storedIn:
Gene Expression Omnibus
qualifier:
not compressed
format:
HTML
accessType:
landing page
primary:
true
authentication:
none
authorization:
none
abbreviation:
EBI
homePage: http://www.ebi.ac.uk/
ID:
SCR:004727
name:
European Bioinformatics Institute
homePage: https://www.ebi.ac.uk/arrayexpress/
ID:
SCR:002964
name:
ArrayExpress

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