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Title: Recurrent TCF12 mutations in anaplastic oligodendroglioma (Part III, genotyping by array)      
dateReleased:
08-15-2015
description:
A Cartes d'Identite des Tumeurs (CIT) project from the french Ligue Nationale Contre le Cancer (); Anaplastic oligodendrogliomas (AOs) are rare primary brain tumors which are generally incurable with few treatment targets identified. Most oligodendrogliomas have chromosome 1p/19q co-deletion and IDH mutation. We analyzed 51 AOs by whole-exome and/or transcriptome sequencing identifying previously reported frequent somatic mutations in CIC and FUBP1 genes. We also identified recurrent mutations in TCF12 (11% of IDHmut-codel) which encodes basic helix-loop-helix (bHLFH) transcription factor 12 A Cartes d'Identite des Tumeurs (CIT) project from the french Ligue Nationale Contre le Cancer (); which is an oligodendrocyte-related transcription factor in IDHmut-codel tumors. Strikingly, the somatic mutations (encoding E548R and R602M substitutions) have not been reported previously in cancer but are identical to germline mutations causing craniosynostosis. Incorporating TCGA data on 43 AO tumors also implicates functional mutation of SMARCA4, NOTCH1, NOTCH2, SETD2, RBPJ and ARID1A/1B. These data are compatible with the combined deregulation of metabolism, chromatin organization/remodeling and Notch-pathway genes in AO oncogenesis. Our analysis provides further insights into the unique and shared pathways driving AO and new targets for therapeutic intervention.
privacy:
not applicable
aggregation:
instance of dataset
ID:
E-MTAB-2772
refinement:
raw
dateSubmitted:
07-18-2014
keywords:
functional genomics
dateModified:
06-09-2015
creators:
Nabila Elarouci
availability:
available
types:
gene expression
name:
Homo sapiens
name:
genotyping design
ID:
A-GEOD-6985
name:
Illumina HumanCNV370-QuadV3 DNA Analysis BeadChip (HumanCNV370-QuadV3_C)
accessURL: https://www.ebi.ac.uk/arrayexpress/files/E-MTAB-2772/E-MTAB-2772.raw.1.zip
storedIn:
ArrayExpress
qualifier:
gzip compressed
format:
TXT
accessType:
download
authentication:
none
authorization:
none
accessURL: https://www.ebi.ac.uk/arrayexpress/files/E-MTAB-2772/E-MTAB-2772.processed.1.zip
storedIn:
ArrayExpress
qualifier:
gzip compressed
format:
TXT
accessType:
download
authentication:
none
authorization:
none
abbreviation:
EBI
homePage: http://www.ebi.ac.uk/
ID:
SCR:004727
name:
European Bioinformatics Institute
homePage: https://www.ebi.ac.uk/arrayexpress/
ID:
SCR:002964
name:
ArrayExpress

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