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Title: Cross-species transcriptomic comparison of in vitro and in vivo mammalian neural cells      
dateReleased:
09-05-2015
description:
We report the first RNA profiing of mammalian neural cells grown in vitro. About 50 million reads are generated by RNA-seq from rat astrocytes, neurons and oligodendrocyte precursor cells in primary culture. These data are compared with theose generated from the correponding mouse neural cells that are acutely purified from brains. Cross-species RNA-seq data analysis revealed hundreds of genes that are differentially expressed between cultured and acutely purified cells. Astrocytes have more such genes compared to neurons and oligodendrocyte precursor cells, indicating that signalling pathways are greatly perturbed in cultured astrocytes. mRNA profiles of rat astrocytes, neurons and oligodendrocyte precursor cells cultured in vitro
privacy:
not applicable
aggregation:
instance of dataset
ID:
E-GEOD-72739
refinement:
raw
alternateIdentifiers:
72739
keywords:
functional genomics
dateModified:
09-12-2015
availability:
available
types:
gene expression
name:
Rattus norvegicus
accessURL: https://www.ebi.ac.uk/arrayexpress/files/E-GEOD-72739/E-GEOD-72739.raw.1.zip
storedIn:
ArrayExpress
qualifier:
gzip compressed
format:
TXT
accessType:
download
authentication:
none
authorization:
none
accessURL: https://www.ebi.ac.uk/arrayexpress/files/E-GEOD-72739/E-GEOD-72739.processed.1.zip
storedIn:
ArrayExpress
qualifier:
gzip compressed
format:
TXT
accessType:
download
authentication:
none
authorization:
none
accessURL: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE72739
storedIn:
Gene Expression Omnibus
qualifier:
not compressed
format:
HTML
accessType:
landing page
primary:
true
authentication:
none
authorization:
none
abbreviation:
EBI
homePage: http://www.ebi.ac.uk/
ID:
SCR:004727
name:
European Bioinformatics Institute
homePage: https://www.ebi.ac.uk/arrayexpress/
ID:
SCR:002964
name:
ArrayExpress

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