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Title: Human cystatin D (CST5) locates in the nucleus at sites of active transcription and regulates gene expression      
dateReleased:
11-04-2015
description:
Cystatin D (CST5) is an inhibitor of several proteases of the cathepsin family that inhibits cell proliferation, migration and invasion of colon carcinoma cells. Some of these effects are unrelated to its antiprotease activity. Here, we use genome-wide expression microarrays to show that cystatin D regulates gene expression (including that of genes encoding transcription factors such as RUNX1, RUNX2, or MEF2C) in HCT116 cells. HCT116 colon adenocarcinoma cell lines stably expressing cystatin D (HCT116-CST5 clone 9 and clone 20), mock-transfected (HCT116-Mock) and un-transfected (HCT116-Untransfected) were generated as described (Álvarez-Díaz et al., 2009, PUBMED:19662683) and genome-wide expression microarrays were obtained to achieve the gene expression profile induced by CST5.
privacy:
not applicable
aggregation:
instance of dataset
ID:
E-GEOD-45904
refinement:
raw
alternateIdentifiers:
45904
keywords:
functional genomics
dateModified:
11-24-2015
availability:
available
types:
gene expression
name:
Homo sapiens
ID:
A-GEOD-16987
name:
[HuGene-1_0-st] Affymetrix Human Gene 1.0 ST Array [CDF: GATExplorer_Ensembl v57]
accessURL: https://www.ebi.ac.uk/arrayexpress/files/E-GEOD-45904/E-GEOD-45904.raw.1.zip
storedIn:
ArrayExpress
qualifier:
gzip compressed
format:
TXT
accessType:
download
authentication:
none
authorization:
none
accessURL: https://www.ebi.ac.uk/arrayexpress/files/E-GEOD-45904/E-GEOD-45904.processed.1.zip
storedIn:
ArrayExpress
qualifier:
gzip compressed
format:
TXT
accessType:
download
authentication:
none
authorization:
none
accessURL: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE45904
storedIn:
Gene Expression Omnibus
qualifier:
not compressed
format:
HTML
accessType:
landing page
primary:
true
authentication:
none
authorization:
none
abbreviation:
EBI
homePage: http://www.ebi.ac.uk/
ID:
SCR:004727
name:
European Bioinformatics Institute
homePage: https://www.ebi.ac.uk/arrayexpress/
ID:
SCR:002964
name:
ArrayExpress

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