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Title: The hypothalamic transcriptome of Negr1 deficient mice      
dateReleased:
11-11-2015
description:
Appetite is largely controlled by hypothalamic neurons. Variation near the Negr1 gene has been significantly associated with increased body mass in multiple human genome-wide association studies. Accordingly, we ablated Negr1 in the hypothalamus of mice and demonstrated this was sufficient to generate a metabolic phenotype. To investigate the molecular mechanisms through which Negr1 influences feeding behaviour, we performed paired-end RNAseq on the Illumina platform in hypothalamic tissue from Negr1 knockout and control mice This data is part of a pre-publication release. For information on the proper use of pre-publication data shared by the Wellcome Trust Sanger Institute (including details of any publication moratoria), please see
privacy:
not applicable
aggregation:
instance of dataset
ID:
E-ERAD-404
refinement:
raw
keywords:
functional genomics
dateModified:
05-17-2016
creators:
The Wellcome Trust Sanger Institute
availability:
available
types:
gene expression
name:
Mus Musculus
accessURL: https://www.ebi.ac.uk/arrayexpress/files/E-ERAD-404/E-ERAD-404.raw.1.zip
storedIn:
ArrayExpress
qualifier:
gzip compressed
format:
TXT
accessType:
download
authentication:
none
authorization:
none
accessURL: https://www.ebi.ac.uk/arrayexpress/files/E-ERAD-404/E-ERAD-404.processed.1.zip
storedIn:
ArrayExpress
qualifier:
gzip compressed
format:
TXT
accessType:
download
authentication:
none
authorization:
none
abbreviation:
EBI
homePage: http://www.ebi.ac.uk/
ID:
SCR:004727
name:
European Bioinformatics Institute
homePage: https://www.ebi.ac.uk/arrayexpress/
ID:
SCR:002964
name:
ArrayExpress

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