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Title: Methylation data as part of an Integrated analysis of oligodendroglial tumours      
dateReleased:
03-11-2016
description:
A Cartes d'Identite des Tumeurs (CIT) project from the french Ligue Nationale Contre le Cancer ( Oligodendroglial tumours (OT) are a heterogeneous group of gliomas. Three molecular subgroups are currently distinguished based on the IDH mutation and the 1p/19q co-deletion. Here we performed an integrated analysis of the transcriptome, genome and methylome of 156 OT. Beyond the 3 well-known molecular classes, our multi-omics classification revealed 3 subgroups within 1p/19q co-deleted tumours, associated with different expression patterns of oligodendroglial progenitor cell (OPC), astrocytic, oligodendrocytic and neuronal lineage genes. The validity of these 3 subgroups was confirmed on public datasets. The OPC-like group was associated with a more aggressive histological and genomic profile and with MYC activation that occurred through various alterations including MYC locus genomic gain, MYC exon 3 hypo-methylation and down-regulation of microRNA-34b/c. In the lower grade glioma TCGA dataset, the OPC-like group was associated with a poorer outcome independently from histological grade. Our study unravels previously unrecognized heterogeneity among 1p/19q co-deleted tumours.
privacy:
not applicable
aggregation:
instance of dataset
ID:
E-MTAB-3903
refinement:
raw
dateSubmitted:
09-15-2015
keywords:
functional genomics
dateModified:
12-09-2016
creators:
Elarouci Nabila
availability:
available
types:
gene expression
name:
Homo sapiens
name:
normalization testing design
ID:
A-MEXP-2255
name:
Illumina Infinium HumanMethylation450 BeadChip
accessURL: https://www.ebi.ac.uk/arrayexpress/files/E-MTAB-3903/E-MTAB-3903.raw.1.zip
storedIn:
ArrayExpress
qualifier:
gzip compressed
format:
TXT
accessType:
download
authentication:
none
authorization:
none
accessURL: https://www.ebi.ac.uk/arrayexpress/files/E-MTAB-3903/E-MTAB-3903.processed.1.zip
storedIn:
ArrayExpress
qualifier:
gzip compressed
format:
TXT
accessType:
download
authentication:
none
authorization:
none
abbreviation:
EBI
homePage: http://www.ebi.ac.uk/
ID:
SCR:004727
name:
European Bioinformatics Institute
homePage: https://www.ebi.ac.uk/arrayexpress/
ID:
SCR:002964
name:
ArrayExpress