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Title: Gene expression profiling of primary HER2-positive breast cancers treated with neoadjuvant trastuzumab      
dateReleased:
03-31-2016
description:
Trastuzumab, a humanized monoclonal antibody directed to the HER2 protein, is the standard-of-care treatment for patients with HER2 positive breast cancer, reducing the risk of relapse and death in patients. Nonetheless, some patients do not benefit from this treatment, underscoring the need to identify patients for whom chemotherapy + trastuzumab is adequate versus patients requiring additional drugs. The series comprised 24 incisional biopsies of breast carcinomas derived from patients that received neoadjuvant trastuzumab based therapy. Gene expression profiling was performed using RNA from frozen core biopsies from 24 patients with primary HER2-positive (HER2+) tumors treated with neoadjuvant chemotherapy and trastuzumab.
privacy:
not applicable
aggregation:
instance of dataset
ID:
E-GEOD-62327
refinement:
raw
alternateIdentifiers:
62327
keywords:
functional genomics
dateModified:
04-01-2016
availability:
available
types:
gene expression
name:
Homo sapiens
ID:
A-GEOD-14951
name:
Illumina HumanHT-12 WG-DASL V4.0 R2 expression beadchip
accessURL: https://www.ebi.ac.uk/arrayexpress/files/E-GEOD-62327/E-GEOD-62327.raw.1.zip
storedIn:
ArrayExpress
qualifier:
gzip compressed
format:
TXT
accessType:
download
authentication:
none
authorization:
none
accessURL: https://www.ebi.ac.uk/arrayexpress/files/E-GEOD-62327/E-GEOD-62327.processed.1.zip
storedIn:
ArrayExpress
qualifier:
gzip compressed
format:
TXT
accessType:
download
authentication:
none
authorization:
none
accessURL: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE62327
storedIn:
Gene Expression Omnibus
qualifier:
not compressed
format:
HTML
accessType:
landing page
primary:
true
authentication:
none
authorization:
none
abbreviation:
EBI
homePage: http://www.ebi.ac.uk/
ID:
SCR:004727
name:
European Bioinformatics Institute
homePage: https://www.ebi.ac.uk/arrayexpress/
ID:
SCR:002964
name:
ArrayExpress

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