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Title: GATA3 induces human T cell commitment following Notch-induced T-lineage specification (expression)      
dateReleased:
04-06-2016
description:
Here, we show that GATA3 induces T-lineage commitment following Notch-induced T-lineage specification through direct regulation of at least 3 distinct processes: repression of NK-cell fate, activation of T-lineage genes to promote further differentiation, and down modulation of Notch signalling activity. Gene expression was measured in RPMI8402 cells after transduction with control, shGATA3 or shTCF1 and culture for 48h. Cells were collected 48h after transduction and sorted for EGFP+. This was performed for 2 replicates.
privacy:
not applicable
aggregation:
instance of dataset
ID:
E-GEOD-76348
refinement:
raw
alternateIdentifiers:
76348
keywords:
functional genomics
dateModified:
04-09-2016
availability:
available
types:
gene expression
name:
Homo sapiens
ID:
A-GEOD-19197
name:
CMGG Human V1.1 60k [Probe Name Version]
accessURL: https://www.ebi.ac.uk/arrayexpress/files/E-GEOD-76348/E-GEOD-76348.raw.1.zip
storedIn:
ArrayExpress
qualifier:
gzip compressed
format:
TXT
accessType:
download
authentication:
none
authorization:
none
accessURL: https://www.ebi.ac.uk/arrayexpress/files/E-GEOD-76348/E-GEOD-76348.processed.1.zip
storedIn:
ArrayExpress
qualifier:
gzip compressed
format:
TXT
accessType:
download
authentication:
none
authorization:
none
accessURL: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE76348
storedIn:
Gene Expression Omnibus
qualifier:
not compressed
format:
HTML
accessType:
landing page
primary:
true
authentication:
none
authorization:
none
abbreviation:
EBI
homePage: http://www.ebi.ac.uk/
ID:
SCR:004727
name:
European Bioinformatics Institute
homePage: https://www.ebi.ac.uk/arrayexpress/
ID:
SCR:002964
name:
ArrayExpress

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