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Title: Identification of Acute megakaryoblastic leukemia (AMKL) deregulated genes by RNAseq      
dateReleased:
05-21-2016
description:
Acute megakaryoblastic leukemia (AMKL) is a heterogeneous disease generally associated with poor prognosis. Gene expression profiles indicate the existence of distinct molecular subgroups, and several genetic alterations have been characterized in the past years, including the t(1;22)(p13;q13) and the trisomy 21 associated with GATA1 mutations. However, the majority of patients do not present known mutations, and the limited access to primary patient leukemic cells impedes the efficient development of novel therapeutic strategies. In this study, using a xenotransplantation approach, we have modeled human pediatric AMKL in immunodeficient mice. Analysis of high-throughput RNA sequencing identified recurrent fusion genes defining new molecular subgroups.
privacy:
not applicable
aggregation:
instance of dataset
ID:
E-MTAB-4697
refinement:
raw
dateSubmitted:
10-08-2012
keywords:
functional genomics
dateModified:
05-12-2016
creators:
Thomas MERCHER
availability:
available
types:
gene expression
name:
Homo sapiens
name:
genetic modification design
accessURL: https://www.ebi.ac.uk/arrayexpress/files/E-MTAB-4697/E-MTAB-4697.raw.1.zip
storedIn:
ArrayExpress
qualifier:
gzip compressed
format:
TXT
accessType:
download
authentication:
none
authorization:
none
accessURL: https://www.ebi.ac.uk/arrayexpress/files/E-MTAB-4697/E-MTAB-4697.processed.1.zip
storedIn:
ArrayExpress
qualifier:
gzip compressed
format:
TXT
accessType:
download
authentication:
none
authorization:
none
abbreviation:
EBI
homePage: http://www.ebi.ac.uk/
ID:
SCR:004727
name:
European Bioinformatics Institute
homePage: https://www.ebi.ac.uk/arrayexpress/
ID:
SCR:002964
name:
ArrayExpress

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