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Title: The effect of Dicer knockdown on the microRNA transcriptional profile of 3.10 medullary epithelial cell (mTEC) cell line      
dateReleased:
06-27-2016
description:
Dicer, also known as endoribonuclease Dicer or helicase with RNase motif, cleaves double-stranded RNA (dsRNA) and pre-microRNA (pre-miRNA) into short mature double-stranded RNA fragments called small interfering RNA and microRNA, respectively. MicroRNAs are potent post-transcriptional regulators in developmental switches, lineage commitment and gene expression regulation. To evaluate their post-transcriptional role in gene expression of Medullary thymic epithelial cells (mTECS) we knocked down Dicer transcript by means of siRNA transfection in a Mus musculus mTEC cell line (3.10 mTEC). The Agilent oligo microarrays were used to determine the large scale microRNA (miRNA) transcriptional profiles of control or Dicer-knockdown 3.10 mTECs.
privacy:
not applicable
aggregation:
instance of dataset
ID:
E-MTAB-4627
refinement:
raw
dateSubmitted:
12-10-2015
keywords:
functional genomics
dateModified:
12-28-2016
creators:
Geraldo Passos
availability:
available
types:
gene expression
name:
Mus musculus
ID:
A-GEOD-10384
name:
Agilent-021828 Unrestricted Mouse miRNA Microarray (V2)
accessURL: https://www.ebi.ac.uk/arrayexpress/files/E-MTAB-4627/E-MTAB-4627.raw.1.zip
storedIn:
ArrayExpress
qualifier:
gzip compressed
format:
TXT
accessType:
download
authentication:
none
authorization:
none
accessURL: https://www.ebi.ac.uk/arrayexpress/files/E-MTAB-4627/E-MTAB-4627.processed.1.zip
storedIn:
ArrayExpress
qualifier:
gzip compressed
format:
TXT
accessType:
download
authentication:
none
authorization:
none
abbreviation:
EBI
homePage: http://www.ebi.ac.uk/
ID:
SCR:004727
name:
European Bioinformatics Institute
homePage: https://www.ebi.ac.uk/arrayexpress/
ID:
SCR:002964
name:
ArrayExpress

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