biomedical and healthCAre Data Discovery Index Ecosystem
biomedical and healthCAre Data Discovery Index Ecosystem
| Title: | A novel Lysyl oxidase like 2 alternative splicing LOXL2 △e13 in esophageal squamous carcinoma cells
|
| dateReleased: |
07-03-2016
|
| description: |
A novel alternative splicing isoform of LOXL2 △e13 was expressed ubiquitously in all cell lines and ESCC tissues. In contrast to the impaired deamination enzymatic activity compared with full length LOXL2, LOXL2 △e13 showed an enhanced ability to promote cell mobility and invasiveness in ESCC cells than full length LOXL2 through a different mechanism. We used cDNA microarrays to identify genes that were differentially expressed upon LOXL2 △ e13 overexpressed. For this purpose, we selected LOXL2 △ e13, WT and empty vector control transfeced ESCC KYSE150 cell lines. Total RNA was extracted,compare the gene expression patterns between LOXL2 △e13, LOXL2 WT and empty vector control transfected cells through the Genechip Primeview Human Gene Expression Array.
|
| privacy: |
not applicable
|
| aggregation: |
instance of dataset
|
| ID: |
E-GEOD-53676
|
| refinement: |
raw
|
| alternateIdentifiers: |
53676
|
| keywords: |
functional genomics
|
| dateModified: |
12-28-2016
|
| creators: |
Guo-Qing Lv
|
| availability: |
available
|
| types: |
gene expression
|
| name: |
Homo sapiens
|
| ID: |
A-GEOD-15207
|
| name: |
GeneChip® PrimeView™ Human Gene Expression Array
|
| accessURL: | https://www.ebi.ac.uk/arrayexpress/files/E-GEOD-53676/E-GEOD-53676.raw.1.zip |
| storedIn: |
ArrayExpress
|
| qualifier: |
gzip compressed
|
| format: |
TXT
|
| accessType: |
download
|
| authentication: |
none
|
| authorization: |
none
|
| accessURL: | https://www.ebi.ac.uk/arrayexpress/files/E-GEOD-53676/E-GEOD-53676.processed.1.zip |
| storedIn: |
ArrayExpress
|
| qualifier: |
gzip compressed
|
| format: |
TXT
|
| accessType: |
download
|
| authentication: |
none
|
| authorization: |
none
|
| accessURL: | https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE53676 |
| storedIn: |
Gene Expression Omnibus
|
| qualifier: |
not compressed
|
| format: |
HTML
|
| accessType: |
landing page
|
| primary: |
true
|
| authentication: |
none
|
| authorization: |
none
|
| abbreviation: |
EBI
|
| homePage: | http://www.ebi.ac.uk/ |
| ID: |
SCR:004727
|
| name: |
European Bioinformatics Institute
|
| homePage: | https://www.ebi.ac.uk/arrayexpress/ |
| ID: |
SCR:002964
|
| name: |
ArrayExpress
|