Title: | A novel Lysyl oxidase like 2 alternative splicing LOXL2 △e13 in esophageal squamous carcinoma cells
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dateReleased: |
07-03-2016
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description: |
A novel alternative splicing isoform of LOXL2 △e13 was expressed ubiquitously in all cell lines and ESCC tissues. In contrast to the impaired deamination enzymatic activity compared with full length LOXL2, LOXL2 △e13 showed an enhanced ability to promote cell mobility and invasiveness in ESCC cells than full length LOXL2 through a different mechanism. We used cDNA microarrays to identify genes that were differentially expressed upon LOXL2 △ e13 overexpressed. For this purpose, we selected LOXL2 △ e13, WT and empty vector control transfeced ESCC KYSE150 cell lines. Total RNA was extracted,compare the gene expression patterns between LOXL2 △e13, LOXL2 WT and empty vector control transfected cells through the Genechip Primeview Human Gene Expression Array.
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privacy: |
not applicable
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aggregation: |
instance of dataset
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ID: |
E-GEOD-53676
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refinement: |
raw
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alternateIdentifiers: |
53676
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keywords: |
functional genomics
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dateModified: |
12-28-2016
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creators: |
Guo-Qing Lv
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availability: |
available
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types: |
gene expression
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name: |
Homo sapiens
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ID: |
A-GEOD-15207
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name: |
GeneChip® PrimeView™ Human Gene Expression Array
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accessURL: | https://www.ebi.ac.uk/arrayexpress/files/E-GEOD-53676/E-GEOD-53676.raw.1.zip |
storedIn: |
ArrayExpress
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qualifier: |
gzip compressed
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format: |
TXT
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accessType: |
download
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authentication: |
none
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authorization: |
none
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accessURL: | https://www.ebi.ac.uk/arrayexpress/files/E-GEOD-53676/E-GEOD-53676.processed.1.zip |
storedIn: |
ArrayExpress
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qualifier: |
gzip compressed
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format: |
TXT
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accessType: |
download
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authentication: |
none
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authorization: |
none
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accessURL: | https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE53676 |
storedIn: |
Gene Expression Omnibus
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qualifier: |
not compressed
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format: |
HTML
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accessType: |
landing page
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primary: |
true
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authentication: |
none
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authorization: |
none
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abbreviation: |
EBI
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homePage: | http://www.ebi.ac.uk/ |
ID: |
SCR:004727
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name: |
European Bioinformatics Institute
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homePage: | https://www.ebi.ac.uk/arrayexpress/ |
ID: |
SCR:002964
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name: |
ArrayExpress
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