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Title: Global miRNA expression profile of head and neck squamous cell carcinoma patients with resistant and sensitive tumors      
dateReleased:
10-25-2016
description:
The aim of the present study was to evaluate miRNAs as response predictors in FFPE head and neck samples from a phase II clinical trial designed to evaluate the feasibility of delivering cisplatin concurrent with radiotherapy after an induction chemotherapy (IC) regimen based on the combination of cisplatin plus paclitaxel in locally advanced head and neck squamous cell carcinoma (HNSCC) patients. For this purpose, we assessed the global miRNA expression profile of 15 HNSCC patients undergoing treatment, in order to identify miRNAs able to segregate resistant tumors from the sensitive ones, thus serving as markers to predict response. The results showed four miRNAs (miR-21, miR-494, miR-720 and miR-923) that were overexpressed in HNSCC FFPE samples.
privacy:
not applicable
aggregation:
instance of dataset
ID:
E-MTAB-4854
refinement:
raw
dateSubmitted:
09-26-2012
keywords:
functional genomics
dateModified:
09-13-2016
creators:
Lidia Maria Rebolho Batista Arantes
availability:
available
types:
gene expression
name:
Homo sapiens
name:
disease state design
ID:
A-MEXP-2289
name:
Agilent human micoRNA microarray (8x15k), Grid Name 021827
accessURL: https://www.ebi.ac.uk/arrayexpress/files/E-MTAB-4854/E-MTAB-4854.raw.1.zip
storedIn:
ArrayExpress
qualifier:
gzip compressed
format:
TXT
accessType:
download
authentication:
none
authorization:
none
accessURL: https://www.ebi.ac.uk/arrayexpress/files/E-MTAB-4854/E-MTAB-4854.processed.1.zip
storedIn:
ArrayExpress
qualifier:
gzip compressed
format:
TXT
accessType:
download
authentication:
none
authorization:
none
abbreviation:
EBI
homePage: http://www.ebi.ac.uk/
ID:
SCR:004727
name:
European Bioinformatics Institute
homePage: https://www.ebi.ac.uk/arrayexpress/
ID:
SCR:002964
name:
ArrayExpress

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