Mountain View
biomedical and healthCAre Data Discovery Index Ecosystem
help Advanced Search
Title: microRNA profiling of serum microRNA from high grade serous ovarian carcinoma      
dateReleased:
01-30-2017
description:
High-grade serous ovarian carcinoma (HGSOC) is the most lethal gynecologic neoplasm, with five-year survival rate below 30%. Early disease detection is of utmost importance to improve the cure rate of HGSOC. Liquid biopsies are now becoming a new paradigm to develop novel biomarkers with diagnostic and prognostic purposes. The focus of this study was to detect the levels of circulating miRNAs in tissues and sera from patients with HGSOC and to evaluate their diagnostic value. To this end, an array-based discovery platform, followed by an innovative statistical approach of data normalization, was exploited, to identify miRNA species selectively expressed in serum of patients with HGSOC. Sera from 106 high grade serous ovarian carcinoma (HGSOC) and 24 healthy controls were used for profiling serum microRNA using a modified version of a commercially available microarray, with the aim of identifying differentially expressed microRNA between tumor patients and healthy controls.
privacy:
not applicable
aggregation:
instance of dataset
ID:
E-MTAB-4667
refinement:
raw
keywords:
functional genomics
dateModified:
01-30-2017
creators:
Luca Beltrame
availability:
available
types:
gene expression
name:
Homo sapiens
ID:
A-MTAB-585
name:
Agilent Human 8x60k MicroRNA Array (miRBase 16.0) with non human spike-ins (Agilent design ID 047209)
accessURL: https://www.ebi.ac.uk/arrayexpress/files/E-MTAB-4667/E-MTAB-4667.raw.1.zip
storedIn:
ArrayExpress
qualifier:
gzip compressed
format:
TXT
accessType:
download
authentication:
none
authorization:
none
accessURL: https://www.ebi.ac.uk/arrayexpress/files/E-MTAB-4667/E-MTAB-4667.processed.1.zip
storedIn:
ArrayExpress
qualifier:
gzip compressed
format:
TXT
accessType:
download
authentication:
none
authorization:
none
abbreviation:
EBI
homePage: http://www.ebi.ac.uk/
ID:
SCR:004727
name:
European Bioinformatics Institute
homePage: https://www.ebi.ac.uk/arrayexpress/
ID:
SCR:002964
name:
ArrayExpress

Feedback?

If you are having problems using our tools, or if you would just like to send us some feedback, please post your questions on GitHub.