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Title: Expression profiling of budding cells in colorectal cancer suggests an EMT-like phenotype and molecular subtype switching      
dateReleased:
02-04-2017
description:
Tumour buds undergo phenotype switching while detaching from the main tumour, as they acquire more migratory characteristics and tend to stop proliferating. Simultaneously, an EMT-like signature is observed in the tumour buds under the form of active WNT, TGF and receptor tyrosine kinase signalling. In addition, FOXA2 and RUNX2 well known transcription factors in other cancer types were also differentially expressed in the buds compared to the main tumour mass, hinting at the potential role in tumour budding and initiation of metastasis in colorectal cancer.
privacy:
not applicable
aggregation:
instance of dataset
ID:
E-MTAB-4065
refinement:
raw
dateSubmitted:
09-21-2015
keywords:
functional genomics
dateModified:
02-03-2017
creators:
Bram Boeckx
availability:
available
types:
gene expression
name:
Homo sapiens
name:
development or differentiation design
accessURL: https://www.ebi.ac.uk/arrayexpress/files/E-MTAB-4065/E-MTAB-4065.raw.1.zip
storedIn:
ArrayExpress
qualifier:
gzip compressed
format:
TXT
accessType:
download
authentication:
none
authorization:
none
accessURL: https://www.ebi.ac.uk/arrayexpress/files/E-MTAB-4065/E-MTAB-4065.processed.1.zip
storedIn:
ArrayExpress
qualifier:
gzip compressed
format:
TXT
accessType:
download
authentication:
none
authorization:
none
abbreviation:
EBI
homePage: http://www.ebi.ac.uk/
ID:
SCR:004727
name:
European Bioinformatics Institute
homePage: https://www.ebi.ac.uk/arrayexpress/
ID:
SCR:002964
name:
ArrayExpress

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