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Title: Deletion of ribosomal protein genes is a common vulnerability in human cancer, particularly in concert with TP53 mutation      
dateReleased:
02-28-2017
description:
Heterozygous inactivating mutations in ribosomal protein genes (RPGs) are associated with hematopoietic and developmental abnormalities, activation of p53, and altered risk of cancer in humans and model organisms. As a part of a large-scale study aimed at identifying associations between RPG deletions, p53 activation, and perturbations of rRNA maturation patterns, we analyzed a series of blood and bone marrow samples from children with acute lymphoblastic leukemia (ALL), as a baseline genomic characterization.
privacy:
not applicable
aggregation:
instance of dataset
ID:
E-MTAB-5450
refinement:
raw
dateSubmitted:
01-23-2017
keywords:
functional genomics
dateModified:
02-28-2017
creators:
Björn Nilsson
availability:
available
types:
gene expression
name:
Homo sapiens
name:
genotyping design
ID:
A-AFFY-142
name:
Affymetrix GeneChip Genome-Wide Human SNP 6.0 [GenomeWideSNP_6]
accessURL: https://www.ebi.ac.uk/arrayexpress/files/E-MTAB-5450/E-MTAB-5450.raw.1.zip
storedIn:
ArrayExpress
qualifier:
gzip compressed
format:
TXT
accessType:
download
authentication:
none
authorization:
none
accessURL: https://www.ebi.ac.uk/arrayexpress/files/E-MTAB-5450/E-MTAB-5450.processed.1.zip
storedIn:
ArrayExpress
qualifier:
gzip compressed
format:
TXT
accessType:
download
authentication:
none
authorization:
none
abbreviation:
EBI
homePage: http://www.ebi.ac.uk/
ID:
SCR:004727
name:
European Bioinformatics Institute
homePage: https://www.ebi.ac.uk/arrayexpress/
ID:
SCR:002964
name:
ArrayExpress

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