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Title: Transcriptional regulation of human pterygial-derived fibroblasts in response to FCS and TGFbeta      
dateReleased:
03-01-2017
description:
Pterygium is an ocular disease that involves a fleshy growth from the conjunctiva across the cornea. It demonstrates accelerated fibroblastic proliferation, matrix deposition and neovascularisation, which is closely linked to inflammation. Growth factor levels are elevated in human pterygium through the enriched blood supply and these are believed to drive physiological events. For this reason, human fibroblasts derived from surgically removed pterygium samples (obtained with full ethical approval) were treated for 24 hours with 10% foetal calf serum (FCS), to mimic an enriched growth factor environment, Transforming growth factor beta2 (TGFβ2), which is often associated with fibrosis and has previously been detected in pterygium, or maintained in serum-free control medium (Eagle's minimum essential medium (EMEM)). To ascertain gross changes in gene expression as a consequence of these treatment groups a HumanHT-12 v4 Expression BeadChip Kit was employed.
privacy:
not applicable
aggregation:
instance of dataset
ID:
E-MTAB-4871
refinement:
raw
dateSubmitted:
12-21-2011
keywords:
functional genomics
dateModified:
01-05-2017
creators:
Ian Michael Wormstone
availability:
available
types:
gene expression
name:
Homo sapiens
ID:
A-MEXP-2072
name:
Illumina HumanHT-12_V4_0_R2_15002873_B
accessURL: https://www.ebi.ac.uk/arrayexpress/files/E-MTAB-4871/E-MTAB-4871.raw.1.zip
storedIn:
ArrayExpress
qualifier:
gzip compressed
format:
TXT
accessType:
download
authentication:
none
authorization:
none
accessURL: https://www.ebi.ac.uk/arrayexpress/files/E-MTAB-4871/E-MTAB-4871.processed.1.zip
storedIn:
ArrayExpress
qualifier:
gzip compressed
format:
TXT
accessType:
download
authentication:
none
authorization:
none
abbreviation:
EBI
homePage: http://www.ebi.ac.uk/
ID:
SCR:004727
name:
European Bioinformatics Institute
homePage: https://www.ebi.ac.uk/arrayexpress/
ID:
SCR:002964
name:
ArrayExpress

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